Document Detail

Lack of association between slow acetylator status and spontaneous lupus erythematosus.
MedLine Citation:
PMID:  2379389     Owner:  NLM     Status:  MEDLINE    
The Chinese in Southeast Asia are recognized as a population group that has a relatively high prevalence of rapid "acetylators" and a relatively high incidence of systemic lupus erythematosus. This study was designed to evaluate the possibility that there were environmental lupus erythematosus provocative substances eliminated by acetylation that resulted in a preponderance of slow acetylators among patients with the disease. We compared acetylator status in 36 Chinese women with mild, stable, and confirmed lupus erythematosus and 36 healthy control subjects matched for age, sex, and ethnic origin. Acetylator status was determined by use of HPLC to assay 5-acetylamino-6-formylamino-3-methyluracil/methylxanthine (AFMU/MX) and AFMU/(AFMU + MX) ratios in urine 1 to 4 hours after drinking a strong cup of coffee (caffeine). By use of parametric and nonparametric methods of analysis, the frequency distribution of AFMU/MX and AFMU/(AFMU + MX) ratios in both the patients and control subjects were determined to be very similar. Thus there was no association between slow acetylator status and lupus erythematosus in the study subjects.
C R Kumana; M M Chan; K L Wong; R W Wong; M Kou; I J Lauder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  48     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-12     Completed Date:  1990-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  208-13     Citation Subset:  AIM; IM    
Department of Medicine, University of Hong Kong.
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MeSH Terms
Caffeine / metabolism
Chromatography, High Pressure Liquid
Lupus Erythematosus, Systemic / chemically induced,  genetics,  metabolism*
Uracil / analogs & derivatives,  analysis
Xanthines / analysis
Reg. No./Substance:
0/Xanthines; 28109-92-4/methylxanthine; 58-08-2/Caffeine; 66-22-8/Uracil; 85438-96-6/5-acetylamino-6-formylamino-3-methyluracil

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