Document Detail

Lack of association between slow acetylator status and spontaneous lupus erythematosus.
MedLine Citation:
PMID:  2379389     Owner:  NLM     Status:  MEDLINE    
The Chinese in Southeast Asia are recognized as a population group that has a relatively high prevalence of rapid "acetylators" and a relatively high incidence of systemic lupus erythematosus. This study was designed to evaluate the possibility that there were environmental lupus erythematosus provocative substances eliminated by acetylation that resulted in a preponderance of slow acetylators among patients with the disease. We compared acetylator status in 36 Chinese women with mild, stable, and confirmed lupus erythematosus and 36 healthy control subjects matched for age, sex, and ethnic origin. Acetylator status was determined by use of HPLC to assay 5-acetylamino-6-formylamino-3-methyluracil/methylxanthine (AFMU/MX) and AFMU/(AFMU + MX) ratios in urine 1 to 4 hours after drinking a strong cup of coffee (caffeine). By use of parametric and nonparametric methods of analysis, the frequency distribution of AFMU/MX and AFMU/(AFMU + MX) ratios in both the patients and control subjects were determined to be very similar. Thus there was no association between slow acetylator status and lupus erythematosus in the study subjects.
C R Kumana; M M Chan; K L Wong; R W Wong; M Kou; I J Lauder
Related Documents :
18931499 - Acardiac fetus with large intestine only. a case report.
16439189 - Twin differences in birth weight: the effects of genotype and prenatal environment on n...
15718359 - Association between erythropoietin in cord blood of twins and size at birth: does it re...
17087539 - In search of shared and nonshared environmental factors in security of attachment: a be...
10636499 - Delivery of breech first twins: a multicenter retrospective study.
9326579 - High-precision 40ar/39ar geochronology and the advent of north america's late cretaceou...
16800419 - A newborn with beals syndrome.
16948619 - Potential for organ donation in victoria: an audit of hospital deaths.
3880879 - Controlled trial of dexamethasone in respirator-dependent infants with bronchopulmonary...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  48     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-12     Completed Date:  1990-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  208-13     Citation Subset:  AIM; IM    
Department of Medicine, University of Hong Kong.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Caffeine / metabolism
Chromatography, High Pressure Liquid
Lupus Erythematosus, Systemic / chemically induced,  genetics,  metabolism*
Uracil / analogs & derivatives,  analysis
Xanthines / analysis
Reg. No./Substance:
0/Xanthines; 28109-92-4/methylxanthine; 58-08-2/Caffeine; 66-22-8/Uracil; 85438-96-6/5-acetylamino-6-formylamino-3-methyluracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Single and multiple doses of oral cimetidine do not change liver blood flow in humans.
Next Document:  Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic S...