| Lack of association between serum magnesium and the risks of hypertension and cardiovascular disease. | |
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MedLine Citation:
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PMID: 20934566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Experimental studies have linked hypomagnesemia with the development of vascular dysfunction, hypertension, and atherosclerosis. Prior clinical studies have yielded conflicting results but were limited by the use of self-reported magnesium intake or short follow-up periods. METHODS: We examined the relationship between serum magnesium concentration and incident hypertension, cardiovascular disease (CVD), and mortality in 3,531 middle-aged adult participants in the Framingham Heart Study offspring cohort. Analyses were performed using Cox proportional hazards regressions, adjusted for traditional CVD risk factors. RESULTS: Follow-up was 8 years for new-onset hypertension (551 events) and 20 years for CVD (554 events). There was no association between baseline serum magnesium and the development of hypertension (multivariable-adjusted hazards ratio per 0.15 mg/dL 1.03, 95% CI 0.92-1.15, P = .61), CVD (0.83, 95% CI 0.49-1.40, P = .49), or all-cause mortality (0.77, 95% CI 0.41-1.45, P = .42). Similar findings were observed in categorical analyses, in which serum magnesium was modeled in categories (<1.5, 1.5-2.2, >2.2 mg/dL) or in quartiles. CONCLUSIONS: In conclusion, data from this large, community-based cohort do not support the hypothesis that low serum magnesium is a risk factor for developing hypertension or CVD. |
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Authors:
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Abigail May Khan; Lisa Sullivan; Elizabeth McCabe; Daniel Levy; Ramachandran S Vasan; Thomas J Wang |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American heart journal Volume: 160 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2010-10-28 Revised Date: 2012-04-27 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 715-20 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / physiology Cardiovascular Diseases / blood, epidemiology Cause of Death / trends Colorimetry Female Follow-Up Studies Heart Diseases / blood*, epidemiology Humans Hypertension / blood*, epidemiology Incidence Magnesium / blood* Male Prognosis Retrospective Studies Risk Factors Survival Rate / trends Time Factors United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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N01 HC025195/HC/NHLBI NIH HHS; R01 HL086875-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7439-95-4/Magnesium |
| Comments/Corrections | |
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