| Lack of association between preference for and dependence on ethanol. | |
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MedLine Citation:
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PMID: 7201379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tests were performed on 60 HS mice to determine preference for ethanol before and after a period of forced ethanol ingestion via a liquid diet treatment. Seizure scores measured 4, 5 and 6 h after the end of the liquid diet treatment showed that moderate degrees of physical dependence had developed. Statistical analyses revealed a significant sex difference only for the amount of ethanol consumed during the liquid diet treatment, with females drinking more than males (on a g/kg basis). Correlation analyses indicated that preference for ethanol was not related to seizure severity or to amount consumed during the liquid diet treatment. A significant drop in preference after ethanol withdrawal was observed when pre- and post-withdrawal preference ratios were compared. These findings are discussed in the context of the usefulness of preference for ethanol as a predictor of alcoholism. |
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Authors:
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D L Allen; H J Fantom; J R Wilson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Drug and alcohol dependence Volume: 9 ISSN: 0376-8716 ISO Abbreviation: Drug Alcohol Depend Publication Date: 1982 Apr |
Date Detail:
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Created Date: 1982-09-10 Completed Date: 1982-09-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7513587 Medline TA: Drug Alcohol Depend Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 119-25 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcoholism
/
complications,
psychology* Animals Behavior, Animal* Choice Behavior* Ethanol Female Humans Male Mice Seizures / etiology Substance Withdrawal Syndrome / etiology |
| Grant Support | |
ID/Acronym/Agency:
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AA-03527/AA/NIAAA NIH HHS; RR-07013-16/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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