| Lack of association between polymorphisms in the prostaglandin F(2α) receptor and solute carrier organic anion transporter family 2A1 genes and intraocular pressure response to prostaglandin analogs. | |
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MedLine Citation:
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PMID: 22060278 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose: To evaluate the association between variants in the prostaglandin F(α) receptor (PTGFR) and solute carrier organic anion transporter family 2A1 (SLCO2A1) genes and intraocular pressure (IOP) response to prostaglandin analogs. Methods: The medical records of subjects with previously diagnosed open angle glaucoma or ocular hypertension were searched for intraocular pressure measurements before and after prescriptions of prostaglandin analogs. Stored DNA samples were genotyped for the following SNPs: rs3753380 (promoter region) and rs3766355 (intronic region) of the prostaglandin F(2α) receptor gene, and rs34550074 (Ala396Thr) of SLCO2A1. The mean change in IOP by genotype was measured. Results: Prostaglandin analogs were prescribed to 267 subjects; 242 (204 right eyes, 205 left eyes) met the inclusion/exclusion criteria for the current study. There was no significant association between genotype and IOP response to prostaglandin analogs (p = 0.48, p = 0.54, p = 0.90). Conclusion: In summary, we found no indication for an association between SNPs in the prostaglandin F(2α) receptor gene or SLCO2A1 and IOP response to prostaglandin analogs in a population of European descent. |
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Authors:
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Catherine A McCarty; Richard Berg; Richard Patchett; Russell A Wilke; James K Burmester1 |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-7 |
Journal Detail:
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Title: Ophthalmic genetics Volume: - ISSN: 1744-5094 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9436057 Medline TA: Ophthalmic Genet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Marshfield Clinic Research Foundation , Marshfield , USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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