| Lack of association between human Oxoguanine Glycosylase 1 (hOGG1) S326C polymorphism and the risk of gastric cancer: a meta-analysis. | |
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MedLine Citation:
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PMID: 22296498 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Results from published studies on the association of Human Oxoguanine Glycosylase 1 (hOGG1) S326C genetic polymorphism with the risk of gastric cancer are inconsistent. We performed a meta-analysis to summarize the possible association. Eleven case-control studies including 2168 cases and 4058 controls were identified from electronic databases (Pubmed, Elsevier Science Direct, Chinese National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), and the Chinese database, Wanfang). No significant association between hOGG1 S326C genetic polymorphism and risk of gastric cancer was observed in the overall analysis. In the stratified analysis based on ethnicity, still no significant association was observed in Europeans, Asians, or Brazilians. This meta-analysis provided evidence that hOGG1 S326C genetic polymorphism was not associated with increased risk of gastric cancer. However, additional studies with large sample size and better study designs are warranted to verify our finding. Keywords: hOGG1, polymorphism, gastric cancer, meta-analysis. |
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Authors:
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R Ding; D J Chen; S L Lin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-02 |
Journal Detail:
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Title: Neoplasma Volume: - ISSN: 0028-2685 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0377266 Medline TA: Neoplasma Country: - |
Other Details:
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Languages: ENG Pagination: 1-2 Citation Subset: - |
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