Document Detail


Lack of association between DQ A and DX A polymorphisms with rheumatoid arthritis and Felty's syndrome.
MedLine Citation:
PMID:  1974834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DQ A and DX A RFLPs were studied in DR4-positive rheumatoid arthritis, Felty's syndrome, and in DR4-positive control subjects, and in the light of the previously documented association between Felty's syndrome and the DQ B 3.1 allele (3b RFLP). In these DR4-positive subjects there were no preferential associations between DQ A or DX A polymorphisms and rheumatoid arthritis or Felty's syndrome and no evidence for unusual DQ A-B haplotypic associations in Felty's or rheumatoid subjects.
Authors:
A S Bate; W Ollier; D M Grennan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Disease markers     Volume:  8     ISSN:  0278-0240     ISO Abbreviation:  Dis. Markers     Publication Date:    1990 Mar-Apr
Date Detail:
Created Date:  1990-09-27     Completed Date:  1990-09-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  55-7     Citation Subset:  IM    
Affiliation:
Rheumatic Diseases Centre, Hope Hospital, Salford.
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / immunology*
Felty's Syndrome / immunology*
Genetic Variation
HLA-D Antigens / genetics*
HLA-DQ Antigens / genetics*
HLA-DR4 Antigen / analysis
Haplotypes
Humans
Polymorphism, Restriction Fragment Length*
Chemical
Reg. No./Substance:
0/HLA-D Antigens; 0/HLA-DQ Antigens; 0/HLA-DR4 Antigen; 0/HLA-Dx antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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