| Lack of association of the apoE4 allele with hippocampal sclerosis dementia. | |
| | |
MedLine Citation:
|
PMID: 8929997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5%, similar to that of a control population and significantly different from the approximately 40% found in Alzheimer's disease (AD) (P < 0.001). These observations suggest that apoE4 is not a risk factor for HSD. |
| | |
Authors:
|
J C Troncoso; C H Kawas; C K Chang; M F Folstein; J C Hedreen |
Related Documents
:
|
12858817 - Binswanger's disease: its association with hypertension and obstructive sleep apnea. 5087877 - Medical aspects of violence. 18679537 - Perispinal etanercept produces rapid improvement in primary progressive aphasia: identi... 18653137 - Morbidity patterns in aged population in southern italy. a survey sampling. 23669057 - What else is in store for autophagy? exocytosis of autolysosomes as a mechanism of tfeb... 11207747 - Legionella: from environmental habitats to disease pathology, detection and control. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Neuroscience letters Volume: 204 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1996 Feb |
Date Detail:
|
Created Date: 1997-01-17 Completed Date: 1997-01-17 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 138-40 Citation Subset: IM |
Affiliation:
|
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Alzheimer Disease / genetics, pathology Apolipoprotein E4 Apolipoproteins E / genetics* Dementia / genetics*, pathology Female Genotype Hippocampus / pathology* Humans Male Nervous System Diseases / genetics*, pathology Paraffin Embedding Sclerosis |
| Grant Support | |
ID/Acronym/Agency:
|
AG05146/AG/NIA NIH HHS; AG07914/AG/NIA NIH HHS; AG08325/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoprotein E4; 0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: mu-Opioid receptor-mediated reduction of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-ac...
Next Document: Comparisons of neurotransmitter concentrations in the synaptosomal preparation of the normotensive a...