Document Detail


Lack of association of the apoE4 allele with hippocampal sclerosis dementia.
MedLine Citation:
PMID:  8929997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5%, similar to that of a control population and significantly different from the approximately 40% found in Alzheimer's disease (AD) (P < 0.001). These observations suggest that apoE4 is not a risk factor for HSD.
Authors:
J C Troncoso; C H Kawas; C K Chang; M F Folstein; J C Hedreen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  204     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1997-01-17     Completed Date:  1997-01-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  138-40     Citation Subset:  IM    
Affiliation:
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / genetics,  pathology
Apolipoprotein E4
Apolipoproteins E / genetics*
Dementia / genetics*,  pathology
Female
Genotype
Hippocampus / pathology*
Humans
Male
Nervous System Diseases / genetics*,  pathology
Paraffin Embedding
Sclerosis
Grant Support
ID/Acronym/Agency:
AG05146/AG/NIA NIH HHS; AG07914/AG/NIA NIH HHS; AG08325/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein E4; 0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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