Document Detail


Lack of association of V beta 8+ T cells with lupus-like syndrome in MRL-lpr/lpr mice.
MedLine Citation:
PMID:  8026533     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the role of V beta 8+ T cells in the development of lupus-like autoimmune syndrome in MRL-lpr/lpr mice, we treated them with the F23.1 anti-V beta 8 monoclonal antibody (mAb) from birth to 4 months of age. Here we report that almost complete depletion of V beta 8+ T cells by the F23.1 mAb treatment neither inhibited nor delayed the development of hypergammaglobulinemia, autoantibody production and autoimmune glomerulonephritis in MRL-lpr/lpr mice. In addition, the F23.1 mAb treatment did not prevent the development of lymphadenopathy and the generation of a CD4-CD8- double-negative T cell subset, characteristically accumulating in lpr lymph nodes. Our results strongly argue against the idea that the V beta 8+ T cells play a critical role in the development of lupus-like autoimmune syndrome in MRL-lpr/lpr mice.
Authors:
L Fossati; R Merino; M Iwamoto; R Lemoine; S Izui
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunology     Volume:  24     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-08-09     Completed Date:  1994-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1717-20     Citation Subset:  IM    
Affiliation:
Department of Pathology, Centre Médical Universitaire, University of Geneva, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / therapeutic use
Antigens, Surface / biosynthesis
Disease Models, Animal
Flow Cytometry
Lupus Erythematosus, Systemic / immunology*,  prevention & control
Lymphatic Diseases / immunology*,  prevention & control
Mice
Mice, Mutant Strains
Receptors, Antigen, T-Cell, alpha-beta / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, Surface; 0/Receptors, Antigen, T-Cell, alpha-beta

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