| Lack of association of G-protein subunit gene C825T polymorphism with left ventricular hypertrophy in essential hypertension. | |
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MedLine Citation:
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PMID: 12011775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of the present study was to determine if there is an association of G-protein b3 subunit (GNB3) gene polymorphisms and left ventricular hypertrophy (LVH) in patients with essential hypertension (EH) in a St. Petersburg population. MATERIAL/METHODS: We examined 135 patients (mean age 48 +/- 7 yrs) with mild to moderate EH recruited from the general population of an outpatient hypertension clinic. Left ventricular mass was measured by echocardiography, and the left ventricular mass index (LVMI) was calculated. The GNB3 C825T genotype was determined by polymerase chain reaction and restriction digestion. RESULTS: 67 patients (50%) were homozygous for the C allele (CC), 56 were heterozygous (CT) (41%) and twelve (9%) were homozygous for the T allele (TT). The distribution of genotypes among the patients was in Hardy-Weinberg equilibrium and did not differ significantly when comparing patients with or without LVH. The frequency of the T allele was only slightly higher in patients with LVH (32%) compared to those without LVH (28%), NS, and the LVMI was similar in patients with the CC, CT and TT genotypes (122.3 +/- 29.8; 118.8 +/- 29.9 and 115.2 +/- 18.3 g/m2, respectively). No significant discrepancies were found among the various genotype groups in posterior wall thickness, interventricular septum thickness, or functional parameters such as ejection fraction, isovolumetric relaxation time and E/A ratio. CONCLUSIONS: These observations clearly suggest the lack of association between left ventricular structure or function and the CNB3 gene variant in the studied population. |
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Authors:
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Eugene V Shlyakhto; Eugene I Shwartz; Yulia B Nefedova; Anna V Zukova; Tatyana A Vinnic; Alexandra O Konrady |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 8 ISSN: 1234-1010 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-15 Completed Date: 2002-10-30 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: CR337-40 Citation Subset: IM |
Affiliation:
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Institute of Cardiovascular Diseases, Pavlov Medical University of St Petersburg, St. Petersburg, Russia. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alleles DNA Restriction Enzymes / metabolism Echocardiography Female Genotype Heterotrimeric GTP-Binding Proteins / chemistry, genetics* Homozygote Humans Hypertension / genetics* Hypertrophy, Left Ventricular / genetics* Male Middle Aged Polymerase Chain Reaction Polymorphism, Genetic* |
| Chemical | |
Reg. No./Substance:
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0/G-protein beta3 subunit; EC 3.1.21.-/DNA Restriction Enzymes; EC 3.6.5.1/Heterotrimeric GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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