| Lack of the appropriate natural killer cell inhibitory receptors in women with spontaneous abortion. | |
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MedLine Citation:
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PMID: 15620464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have revealed that women with unexplained recurrent spontaneous abortions have a limited repertoire of inhibitory KI receptors (inhKIRs) and that the inhKIRs they possess do not have specificity for the human leukocyte antigen (HLA)-Cw molecules that would be expressed on trophoblast. We sought to confirm these findings by direct definition of maternal inhKIR and trophoblastic HLA-Cw allotypes on the placental material of spontaneously missed pregnancies. The study included 30 women undergoing vacuum uterine curettage for first-trimester missed pregnancy (group A; n = 15) or for elective termination of normal pregnancy (group C, n = 15). DNA extracted from isolated decidual and trophoblastic cells was used for molecular detection of maternal inhKIRs (2DL1, 2DL2, 2DL3) and fetal HLA-Cw alleles, respectively. The results revealed that in the group of women who experienced abortion, 60% did not have the full repertoire of three inhKIRs (group A vs group C; p = 0.006); that in five of 15 patients (none in the controls), no epitope matching existed between maternal inhKIRs and trophoblastic HLA-Cw alleles (group A vs group C; p = 0.01); and that more cases were found with limited epitope matching (less than three inhKIRs with specificity for fetal HLA-Cw alleles). The results provide additional evidence that in some cases of spontaneous abortions, the women lack the appropriate inhKIRs to interact with the HLA-Cw molecules on trophoblasts and to deliver signals to inhibit natural killer cell activation and protect the embryo. |
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Authors:
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M Varla-Leftherioti; M Spyropoulou-Vlachou; T Keramitsoglou; M Papadimitropoulos; C Tsekoura; O Graphou; C Papadopoulou; M Gerondi; C Stavropoulos-Giokas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human immunology Volume: 66 ISSN: 0198-8859 ISO Abbreviation: Hum. Immunol. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-12-28 Completed Date: 2005-10-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8010936 Medline TA: Hum Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 65-71 Citation Subset: IM |
Affiliation:
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Department of Immunobiology, Helena Venizelou Maternity Hospital, 11521 Athens, Greece. gr1bmdr@hol.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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immunology* Decidua / immunology Female HLA-C Antigens / immunology* Humans Killer Cells, Natural / immunology* Lymphocyte Activation / immunology Placenta / immunology Pregnancy Receptors, Immunologic / immunology* Trophoblasts / immunology* |
| Chemical | |
Reg. No./Substance:
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0/HLA-C Antigens; 0/HLA-CW 12032 protein, human; 0/Receptors, Immunologic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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