Document Detail


Lack of the appropriate natural killer cell inhibitory receptors in women with spontaneous abortion.
MedLine Citation:
PMID:  15620464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have revealed that women with unexplained recurrent spontaneous abortions have a limited repertoire of inhibitory KI receptors (inhKIRs) and that the inhKIRs they possess do not have specificity for the human leukocyte antigen (HLA)-Cw molecules that would be expressed on trophoblast. We sought to confirm these findings by direct definition of maternal inhKIR and trophoblastic HLA-Cw allotypes on the placental material of spontaneously missed pregnancies. The study included 30 women undergoing vacuum uterine curettage for first-trimester missed pregnancy (group A; n = 15) or for elective termination of normal pregnancy (group C, n = 15). DNA extracted from isolated decidual and trophoblastic cells was used for molecular detection of maternal inhKIRs (2DL1, 2DL2, 2DL3) and fetal HLA-Cw alleles, respectively. The results revealed that in the group of women who experienced abortion, 60% did not have the full repertoire of three inhKIRs (group A vs group C; p = 0.006); that in five of 15 patients (none in the controls), no epitope matching existed between maternal inhKIRs and trophoblastic HLA-Cw alleles (group A vs group C; p = 0.01); and that more cases were found with limited epitope matching (less than three inhKIRs with specificity for fetal HLA-Cw alleles). The results provide additional evidence that in some cases of spontaneous abortions, the women lack the appropriate inhKIRs to interact with the HLA-Cw molecules on trophoblasts and to deliver signals to inhibit natural killer cell activation and protect the embryo.
Authors:
M Varla-Leftherioti; M Spyropoulou-Vlachou; T Keramitsoglou; M Papadimitropoulos; C Tsekoura; O Graphou; C Papadopoulou; M Gerondi; C Stavropoulos-Giokas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human immunology     Volume:  66     ISSN:  0198-8859     ISO Abbreviation:  Hum. Immunol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-28     Completed Date:  2005-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-71     Citation Subset:  IM    
Affiliation:
Department of Immunobiology, Helena Venizelou Maternity Hospital, 11521 Athens, Greece. gr1bmdr@hol.gr
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / immunology*
Decidua / immunology
Female
HLA-C Antigens / immunology*
Humans
Killer Cells, Natural / immunology*
Lymphocyte Activation / immunology
Placenta / immunology
Pregnancy
Receptors, Immunologic / immunology*
Trophoblasts / immunology*
Chemical
Reg. No./Substance:
0/HLA-C Antigens; 0/HLA-CW 12032 protein, human; 0/Receptors, Immunologic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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