Document Detail


Lack of anion effect on volume expansion natriuresis in the developing canine kidney.
MedLine Citation:
PMID:  3025284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The renal response to volume expansion with sodium chloride or sodium bicarbonate was studied in 15 newborn and 13 adult dogs. Proximal and distal nephron function were estimated using the technique of distal nephron blockade. Fractional sodium reabsorption was 99.0 +/- 0.3% in newborn and 96.6 +/- 0.06% in adult during the NaCl expansion (P less than 0.01) and 98.1 +/- 0.7% in the newborn and 93.2 +/- 0.7% in the adult during NaHCO3 expansion (P less than 0.001). With either anion the higher fractional sodium reabsorption in the newborn was due to reabsorption of a greater fraction of the load presented to the distal nephron segment. The percent of the distal sodium load that was reabsorbed was 98.0 +/- 0.6% in the newborn and 92.2 +/- 1.0% in the adult during NaCl expansion, and 96.1 +/- 1.3% in the newborn and 81.5 +/- 2.4% in the adult during NaHCO3 expansion. Differences in distal nephron chloride, potassium and bicarbonate reabsorption among the groups support the hypothesis that the enhanced distal sodium reabsorption in the newborn occurred largely in the ascending loop of Henle with NaCl expansion, while it occurred in the late distal and cortical collecting tubules with NaHCO3 expansion. There was no difference between the natriuretic responses to NaCl or NaHCO3 in the newborn (P greater than 0.20); however, the natriuretic response to NaCl was less than that to NaHCO3 in the adult (P less than 0.001). This suggests that the bulk of the sodium that escaped reabsorption in Henle's loop during NaHCO3 expansion was reabsorbed in the late distal tubule in the newborn, but not in the adult.
Authors:
J M Lorenz; L I Kleinman; T A Disney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  8     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-02-06     Completed Date:  1987-02-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  395-410     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Anions
Bicarbonates / pharmacology*
Dogs
Electrolytes / metabolism
Female
Kidney / drug effects,  growth & development,  physiology*
Kidney Tubules, Distal / drug effects
Kidney Tubules, Proximal / drug effects
Male
Natriuresis / drug effects*
Sodium / pharmacology*
Sodium Bicarbonate
Sodium Chloride / pharmacology*
Grant Support
ID/Acronym/Agency:
MCT-000174/CT/CIT NIH HHS; RR-00068-18-52/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Anions; 0/Bicarbonates; 0/Electrolytes; 144-55-8/Sodium Bicarbonate; 7440-23-5/Sodium; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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