Document Detail

Lack of agreement between left ventricular volumes and ejection fraction determined by two-dimensional echocardiography and contrast cineangiography in postinfarction patients.
MedLine Citation:
PMID:  11262534     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the agreement between left ventricular (LV) volumes and ejection fraction (EF) determined by two-dimensional echocardiography (2-D echo) and by cineangiography in postinfarction patients.
DESIGN: LV end-diastolic and end-systolic volumes indexed (EDVI and ESVI) to body surface area as well as EF were determined by both methods in all patients.
SETTING: Multicenter trial conducted in five university hospitals.
PATIENTS: 63 patients, 61 male, two female, mean age 55.5 +/- 10.4 years, suffering from a recent myocardial infarction. Eighty-one pairs of measurements were available.
METHODS: The results of biplane 2-D echo measures, using apical four-chamber (4C) and two-chamber (2C) views were compared to those of a 30 degrees right anterior oblique cineangiography projection, using either the apical method of discs or the area-length 2-D echo method. Moreover, eyeball EF was estimated at 2-D echo and cineangiography, and was compared to the conventional methods. The agreement between results was assessed by the Bland and Altman method.
RESULTS: The agreement between 2-D echo and cineangiography results was poor. Mean differences (MD) were -21.8 (EDVI, ml/m(2)), -9.5 (ESVI, ml/m(2)), and -0.9 (EF, %), respectively for 2-D echo method of discs versus cineangiography, and -23.2, -9.3, and -5.7 for area-length 2-D echo versus cineangiography. For EF (%), MD was -3.6 for eyeball cineangiography versus cineangiography, -1.3 for eyeball 2-D echo versus method of discs, and +0.30 for eyeball 2-D echo versus area-length 2-D echo, respectively. Two-dimensional echo is likely to underestimate LV volumes compared to cineangiography, especially for largest volumes. Even for EF, discrepancies are large, with a lack of agreement of 21%-25% between conventional methods, but agreement is better between eyeball EF and usual methods.
CONCLUSIONS: Even with modern echocardiographic devices, agreement between 2-D echo and cineangiography-derived LV volumes and EF remains moderate, and both methods must not be considered interchangeable in clinical practice.
Y Bernard; N Meneveau; S Boucher; D Magnin; T Anguenot; F Schiele; A Vuillemenot; J P Bassand
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  18     ISSN:  0742-2822     ISO Abbreviation:  Echocardiography     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-23     Completed Date:  2001-07-12     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-22     Citation Subset:  IM    
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / administration & dosage
Cineangiography / methods*
Echocardiography, Doppler / methods*
Follow-Up Studies
Middle Aged
Myocardial Infarction / drug therapy,  radiography*,  ultrasonography*
Observer Variation
Perindopril / administration & dosage
Sensitivity and Specificity
Severity of Illness Index
Stroke Volume*
Ventricular Function, Left*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; Y5GMK36KGY/Perindopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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