| Lack of acute cardioprotective effect from preischaemic erythropoietin administration in a porcine coronary occlusion model. | |
| | |
MedLine Citation:
|
PMID: 16117735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Recombinant human erythropoietin (rhEPO) has been proposed to possess important tissue protective, apart from haematopoietic, effects. Cardioprotective effects have thus been reported in rodents exposed to myocardial ischaemia. Pathways common to the mediation of ischaemic preconditioning may be involved. Before clinical testing such possible cardioprotective effects needs assessment in an experimental large animal model with closer similarity to human ischaemic pathophysiology. METHODS: A control group and two rhEPO groups were studied. EPO1 pigs were given EPO corresponding to the early window and EPO2 pigs to the early and late window of ischaemic preconditioning in a closed chest, catheter-based, porcine coronary occlusion model (45 min of occlusion of the left anterior descending artery). Infarct size as a proportion of the ischaemic area (IS/AAR) was measured in vivo by myocardial perfusion imaging (MPI) and postmortem by a histochemical procedure (at 150 min of reperfusion). RESULTS: IS/AAR did not differ significantly between control (C), EPO1 and EPO2 groups, neither measured by MPI (mean+/-SD for C: 0.87+/-0.13; EPO1: 0.92+/-0.08; EPO2: 0.87+/-0.11), nor histochemically (mean+/-SD for C: 0.64+/-0.20; EPO1: 0.75+/-0.17; EPO2: 0.80+/-0.07). In the EPO2 group mean arterial pulmonary pressure and dP/dtmax were increased compared with control group. CONCLUSION: Despite promising results from studies in rodents, rhEPO did not reduce infarct size measured after 2.5 h of reperfusion in our porcine model. |
| | |
Authors:
|
Jens Kristensen; Michael Maeng; Michael Rehling; Jette S Berg; Ulrik M Mortensen; Søren S Nielsen; Torsten T Nielsen |
Related Documents
:
|
20594525 - Catheter-directed intra-arterial abciximab administration for acute thrombotic occlusio... 19157895 - Development of diaphragmatic weakness after transcatheter arterial chemoembolization of... 6173005 - Functional occlusion of a cilioretinal artery. 21861745 - A case of contrast-induced encephalopathy using iodixanol. 9930505 - Daily and long-term balloon dilation via minitracheostomy in cicatric bronchial stenosis. 22418615 - The arterial supply of the coracoid process. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical physiology and functional imaging Volume: 25 ISSN: 1475-0961 ISO Abbreviation: Clin Physiol Funct Imaging Publication Date: 2005 Sep |
Date Detail:
|
Created Date: 2005-08-24 Completed Date: 2006-01-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101137604 Medline TA: Clin Physiol Funct Imaging Country: England |
Other Details:
|
Languages: eng Pagination: 305-10 Citation Subset: IM |
Affiliation:
|
Department of Clinical Physiology and Nuclear Medicine, Aarhus University Hospital, Skejby Hospital, Aarhus, Denmark. jenskristensen@dadlnet.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects Cardiac Output / drug effects Cardiotonic Agents / pharmacology* Coronary Stenosis / physiopathology*, radionuclide imaging Disease Models, Animal Erythropoietin, Recombinant / pharmacology* Myocardial Infarction / physiopathology, radionuclide imaging Myocardial Ischemia / physiopathology Swine Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents; 0/Erythropoietin, Recombinant |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of hormone replacement therapy and/or exercise on skeletal muscle attenuation in postmeno...
Next Document: Ultraviolet radiation--immune response