| Lack of CbrB in Pseudomonas putida affects not only amino acids metabolism but also different stress responses and biofilm development. | |
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MedLine Citation:
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PMID: 20553554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The CbrAB two-component system has been described in certain species of Pseudomonads as a global regulatory system required for the assimilation of several amino acids (e.g. histidine, proline or arginine) as carbon or carbon and nitrogen sources. In this work, we used global gene expression and phenotypic analyses to characterize the roles of the CbrAB system in Pseudomonas putida. Our results show that CbrB is involved in coordination with the nitrogen control system activator, NtrC, in the uptake and assimilation of several amino acids. In addition, CbrB affects other carbon utilization pathways and a number of apparently unrelated functions, such as chemotaxis, stress tolerance and biofilm development. Based on these new findings, we propose that CbrB is a high-ranked element in the regulatory hierarchy of P. putida that directly or indirectly controls a variety of metabolic and behavioural traits required for adaptation to changing environmental conditions. |
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Authors:
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Cristina I Amador; Inés Canosa; Fernando Govantes; Eduardo Santero |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Environmental microbiology Volume: 12 ISSN: 1462-2920 ISO Abbreviation: Environ. Microbiol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-17 Completed Date: 2010-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883692 Medline TA: Environ Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 1748-61 Citation Subset: IM |
Affiliation:
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Centro Andaluz de Biología del Desarrollo/ CSIC/ Universidad Pablo de Olavide, Carretera de Utrera, Km. 1. 41013 Seville, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Bacterial Proteins / genetics, metabolism* Biofilms / growth & development* Gene Expression Regulation, Bacterial Gene Regulatory Networks Genome, Bacterial Metals / chemistry Microarray Analysis Molecular Sequence Data PII Nitrogen Regulatory Proteins / genetics, metabolism Pseudomonas putida / genetics, metabolism, physiology* Stress, Physiological* Transcription Factors / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Bacterial Proteins; 0/Metals; 0/PII Nitrogen Regulatory Proteins; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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