Document Detail


Lack of CD4⁺CD25⁺FOXP3⁺ regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki disease.
MedLine Citation:
PMID:  23340699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Lack of CD4(+)CD25(+)FOXP3(+) Tregs before treatment may predict resistance to IVIg therapy in patients with KD.
Authors:
Yu Hirabayashi; Yoshiyuki Takahashi; Yinyan Xu; Kazuyuki Akane; Itzel Bustos Villalobos; Yusuke Okuno; Shinji Hasegawa; Hideki Muramatsu; Asahito Hama; Taichi Kato; Seiji Kojima
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2013-01-23
Journal Detail:
Title:  European journal of pediatrics     Volume:  172     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-24     Completed Date:  2014-01-30     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  833-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antigens, CD4 / metabolism
Biological Markers / metabolism
CD4 Lymphocyte Count
Case-Control Studies
Child
Child, Preschool
Coronary Artery Disease / complications,  immunology
Drug Resistance / immunology*
Female
Flow Cytometry
Forkhead Transcription Factors / metabolism
Humans
Immunoglobulins, Intravenous / immunology,  therapeutic use*
Immunologic Factors / immunology,  therapeutic use*
Infant
Interleukin-2 Receptor alpha Subunit / metabolism
Male
Middle Aged
Mucocutaneous Lymph Node Syndrome / complications,  drug therapy*,  immunology
T-Lymphocytes, Regulatory / metabolism*
Young Adult
Chemical
Reg. No./Substance:
0/Antigens, CD4; 0/Biological Markers; 0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/IL2RA protein, human; 0/Immunoglobulins, Intravenous; 0/Immunologic Factors; 0/Interleukin-2 Receptor alpha Subunit

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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