Document Detail

Lack of association between urinary iodine excretion and successful thyroid ablation in thyroid cancer patients.
MedLine Citation:
PMID:  19858316     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Low-iodine diet is prescribed before (131)I administration in patients with differentiated thyroid cancer, although no study has properly quantified its clinical benefit. OBJECTIVE: Our study aimed to evaluate the association between urinary iodine excretion (UIE) and (131)I ablation by correlating UIE with the rate of successful ablation. PATIENTS: We retrospectively studied 201 differentiated thyroid cancer patients who had received (131)I therapy and posttherapy whole-body scan (WBS) for remnant ablation after either thyroid hormone withdrawal (THW group, n = 125) or recombinant human TSH (rhTSH group, n = 76). The outcome of thyroid ablation was assessed using two different criteria: no visible uptake at control WBS 8-12 months after ablation or no visible uptake plus undetectable stimulated serum thyroglobulin (Tg). RESULTS: According to the criterion of no visible uptake, 84.6% of the patients were successfully ablated, with no significant difference between THW and rhTSH groups. Mean UIE at the time of ablation was 132 +/- 160 microg/liter, not significantly different between patients of the THW and rhTSH groups. There was no significant difference in UIE between ablated or nonablated patients both in the whole group and the rhTSH or THW groups. According to the criterion of no visible uptake plus undetectable stimulated serum Tg (in anti-Tg negative patients) at control WBS 8-12 months after ablation, UIE was not significantly different in ablated and nonablated patients. CONCLUSIONS: Our study indicates that the body iodine content is not an important determinant of thyroid ablation, when preparing the patients with either THW or rhTSH.
Hernan P Tala Jury; Maria Grazia Castagna; Carla Fioravanti; Claudia Cipri; Ernesto Brianzoni; Furio Pacini
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-26
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  95     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-08     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230-7     Citation Subset:  AIM; IM    
University of Siena, Viale Bracci 1, 53100 Siena, Italy.
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MeSH Terms
Carcinoma / diagnosis,  pathology,  radiotherapy*,  urine
Iodine Radioisotopes / therapeutic use*,  urine*
Middle Aged
Neoplasm, Residual / diagnosis
Thyroid Neoplasms / diagnosis,  pathology,  radiotherapy*,  urine
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Iodine Radioisotopes

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