| Lack of Association between the Thr431Asn and Arg83Lys Polymorphisms of the ROCK2 Gene and Diabetic Retinopathy. | |
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MedLine Citation:
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PMID: 20961215 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: To analyze the genotype distributions and allele frequencies for ROCK2 Thr431Asn and Arg83Lys polymorphisms among the diabetic retinopathy patients in a Turkish population. Methods: In this case-control study, 335 patients with diabetes mellitus were recruited and divided into three groups according to non-proliferative (n = 127), proliferative (n = 85) diabetic retinopathy, and no retinopathy (n = 123, served as a diabetic control group). Genomic DNA from the patients, and the nondiabetic healthy control cases (n = 132) was analyzed by real-time PCR using a Light-Cycler. Results: Neither genotype distributions nor the allele frequencies for the Thr431Asn or Arg83Lys polymorphisms showed a significant difference between the groups. The haplotypes were also not significantly associated with diabetic retinopathy. Conclusion: These results suggest that there were no evidence for an association of ROCK2 gene Thr431Asn and Arg83Lys polymorphisms with diabetes or diabetic retinopathy in the Turkish population. |
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Authors:
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Abdullah T Demiryurek; Ibrahim Erbagci; Serdar Oztuzcu; Belgin Alasehirli; Esma Ozkara; Mehmet Seker; Ayhan Sönmez; Muge Ozsan; Celalettin Camci |
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Publication Detail:
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Type: Journal Article Date: 2010-10-20 |
Journal Detail:
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Title: Current eye research Volume: 35 ISSN: 1460-2202 ISO Abbreviation: Curr. Eye Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 1128-34 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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