Document Detail


Lack of Association Between the 135G/C Rad51 Gene Polymorphism and the Risk of Colorectal Cancer Among Polish Population.
MedLine Citation:
PMID:  22935458     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
One of the major causes of carcinogenesis is loss of genome stability. RAD51 in process of homologous recombination (HR) played crucial role in maintenance integrity of genome through initiate of DNA double strand breaks repair. Presence of single nucleotide polymorphism (SNP) in RAD51 gene could change the capacity of DNA repair and altered the response to damaging agents. Research on potential impact of genetic variability on development and progression CRC may contribute to setting new genetic markers or/and determined individual susceptibility to CRC.The aim of the study. This study was designed to evaluate the effect of 135 G/C (rs1801320) RAD51 polymorphism located in the 5' untraslated region on the risk and progression of CRC.Material and methods. The subjects consisted of histologically confirmed colorectal cancer (n = 200) and controls (n = 200) with lack of previous history of cancer. The distribution of genotypes was determined by restriction fragment length polymorphism PCR (RFLP - PCR). Statistical analysis was based on multivariate regression model.Results and conclusion. Our study reveal no significance association of 135 G/C RAD51 polymorphism with occurrence and progression of colorectal cancer.
Authors:
Bartosz Mucha; Karolina Przybyłowska-Sygut; Lukasz Dziki; Adam Dziki; Andrzej Sygut; Ireneusz Majsterek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Polski przeglad chirurgiczny     Volume:  84     ISSN:  0032-373X     ISO Abbreviation:  Pol Przegl Chir     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376426     Medline TA:  Pol Przegl Chir     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  358-62     Citation Subset:  IM    
Affiliation:
Department of Clinical Chemistry and Biochemistry, Medical University in Łódź
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