Document Detail


Labyrinthine lesions and motion sickness susceptibility.
MedLine Citation:
PMID:  17256169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The angular vestibulo-ocular reflex (aVOR) has a fast pathway, which mediates compensatory eye movements, and a slow (velocity storage) pathway, which determines its low frequency characteristics and orients eye velocity toward gravity. We have proposed that motion sickness is generated through velocity storage, when its orientation vector, which lies close to the gravitational vertical, is misaligned with eye velocity during head motion. The duration of the misalignment, determined by the dominant time constant of velocity storage, causes the buildup of motion sickness. To test this hypothesis, we studied bilateral labyrinthine-defective subjects with short vestibular time constants but normal aVOR gains for their motion sickness susceptibility. Time constants and gains were taken from rotational responses. Motion sickness was generated by rolling the head while rotating, and susceptibility was assessed by the number of head movements made before reaching intolerable levels of nausea. More head movements signified lower motion sickness susceptibility. Labyrinthine-defective subjects made more head movements on their first exposure to roll while rotating than normals (39.8 +/- 7.2 vs 13.7 +/- 5.5; P < 0.0001). Normals were tested eight times, which habituated their time constants and reduced their motion sickness susceptibility. Combining data from all subjects, there was a strong inverse relationship between time constants and number of head movements (r = 0.94), but none between motion sickness susceptibility and aVOR gains. This provides further evidence that motion sickness is generated through velocity storage, not the direct pathway, and suggests that motion sickness susceptibility can be reduced by reducing the aVOR time constant.
Authors:
Mingjia Dai; Theodore Raphan; Bernard Cohen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-01-26
Journal Detail:
Title:  Experimental brain research     Volume:  178     ISSN:  0014-4819     ISO Abbreviation:  Exp Brain Res     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-03     Completed Date:  2007-08-24     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  477-87     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Disease Susceptibility*
Female
Head Movements / physiology
Humans
Labyrinth Diseases / complications*
Male
Middle Aged
Motion Sickness / etiology*
Reflex, Vestibulo-Ocular / physiology*
Rotation
Grant Support
ID/Acronym/Agency:
DC05204/DC/NIDCD NIH HHS; DC5222/DC/NIDCD NIH HHS; EY01867/EY/NEI NIH HHS; P30 DC005204/DC/NIDCD NIH HHS; R01 DC007847/DC/NIDCD NIH HHS
Comments/Corrections

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