| Laboratory tests to assess patients with rheumatoid arthritis: advantages and limitations. | |
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MedLine Citation:
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PMID: 19962617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Laboratory tests provide the most definitive information for diagnosing and managing many diseases, and most patients look to laboratory tests as the most important information from a medical visit. Most patients who have rheumatoid arthritis (RA) have a positive test for rheumatoid factor and anticyclic citrullinated peptide (anti-CCP) antibodies, as well as an elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). More than 30% 40% of patients with RA, however, have negative tests for rheumatoid factor or anti-CCP antibodies or a normal ESR or CRP. More than 30% of patients with RA, however, have negative tests for rheumatoid factor or anti-CCP antibodies, and 40% have a normal ESR or CRP. These observations indicate that, although they can be helpful to monitor certain patients, laboratory measures cannot serve as a gold standard for diagnosis and management in all individual patients with RA or any rheumatic disease. Physicians and patients would benefit from an improved understanding of the limitations of laboratory tests in diagnosis and management of patients with RA. |
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Authors:
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Theodore Pincus; Tuulikki Sokka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Rheumatic diseases clinics of North America Volume: 35 ISSN: 1558-3163 ISO Abbreviation: Rheum. Dis. Clin. North Am. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-12-07 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708093 Medline TA: Rheum Dis Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 731-4, vi-vii Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Department of Medicine, New York University School of Medicine and NYU Hospital for Joint Diseases, Room 1608, 301 East 17th Street, New York, NY 10003, USA. tedpincus@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis, Rheumatoid
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blood,
diagnosis*,
immunology* Biological Markers / blood* Blood Sedimentation C-Reactive Protein / metabolism Humans Immunologic Tests / standards* Peptides, Cyclic / immunology Rheumatoid Factor / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Peptides, Cyclic; 0/cyclic citrullinated peptide; 9007-41-4/C-Reactive Protein; 9009-79-4/Rheumatoid Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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