Document Detail

Laboratory procedures for cases of suspected infant botulism.
MedLine Citation:
PMID:  551514     Owner:  NLM     Status:  MEDLINE    
The recent development and evaluation of procedures for examination of fecal specimens for botulinal toxin and Clostridium botulinum have provided the means by which infant botulism can be recognized. The toxicity for mice of fecal extracts containing botulinal toxin can be neutralized with specific botulinal antitoxin. The presence of C. botulinum in the feces is detected by demonstrating the presence of botulinal toxin in enrichment culture supernatant by means of toxicity tests in mice. C. botulinum is isolated by streaking enrichment cultures on egg yolk agar and picking typical lipase-positive colonies. The experience of both the Center for Disease Control (CDC) Botulism Laboratory and other laboratories has been that botulinal toxin and C. botulinum are rarely, if ever, found in the feces of humans (infants or older people) not afflicted with botulism. Results of the examination in the CDC laboratory of specimens from 24 babies with infant botulism are given.
C L Hatheway
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  1     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1979 Jul-Aug
Date Detail:
Created Date:  1980-11-20     Completed Date:  1980-11-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  647-51     Citation Subset:  IM    
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MeSH Terms
Botulinum Toxins / analysis,  blood
Botulism / diagnosis*
Culture Techniques
Feces / analysis
Mice, Inbred ICR
Reg. No./Substance:
0/Botulinum Toxins

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