| Laboratory medicine: the precursors strike back. | |
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MedLine Citation:
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PMID: 21837931 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Laboratory Medicine represents a major component of healthcare and nowadays it is involved in more than seventy percent of medical decisions. The value of any innovative laboratory test will depend on its clinical sensitivity and specificity. This clinical value is of course influenced by the analytical performance and reliability of the assay. Some spectacular advances in the understanding of circulating forms were recently accomplished with an emphasis place on prohormones and analytes precursors. Release of prohormones in the blood flow may be of major impact to improve diagnosis and risk stratification but may also influence the analytical specificity of some commercial assays. The goal of this short review is to discuss some perspectives related to some analytes' precursors that have recently been evidenced to affect assay specificity or increase assay discriminatory power. |
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Authors:
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D Gruson; C Lindberg |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta clinica Belgica Volume: 66 ISSN: 0001-5512 ISO Abbreviation: Acta Clin Belg Publication Date: 2011 May-Jun |
Date Detail:
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Created Date: 2011-08-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370306 Medline TA: Acta Clin Belg Country: Belgium |
Other Details:
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Languages: eng Pagination: 216-20 Citation Subset: IM |
Affiliation:
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Department of Laboratory Medicine, Cliniques Universitaires St-Luc, Brussels, Belgium. damien.gruson@uclouvain.be |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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