Document Detail

Laboratory medicine in neonatal sepsis and inflammation.
MedLine Citation:
PMID:  22958009     Owner:  NLM     Status:  In-Data-Review    
The high incidence of neonatal sepsis worldwide and the considerably high mortality rate of severe sepsis and septic shock call for an earlier diagnosis and more accurate monitoring of the disease. Conventional laboratory tests, such as white blood cell count (WBC) and differential count, micro-erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) have a number of limitations associated with their limited sensitivity in the early phase of the disease and their non-specific increase in the course of various severe neonatal clinical conditions like asphyxia, meconium aspiration and prolonged rupture of membranes. Next-generation biomarkers encompass new molecular tests, accurate measurement of the proteins and enzymes mainly involved in the innate immunity biochemical pathways, application of proteomics and metabolomics for risk stratification and prognosis, and the clinical use of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) for the identification of various bacteria and yeasts. The availability of sophisticated biochemical and molecular tests and of innovative technologies can significantly improve baby outcomes in terms of earlier and more accurate diagnosis, tailored therapeutic treatment, shorter hospitalization and thus minimized complications, and ultimately can prevent and monitor nosocomial and healthcare-associated infections. As a consequence, costs can be significantly reduced over a full cycle of care by investing in high quality laboratory medicine.
Michele Mussap
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  25 Suppl 4     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  24-6     Citation Subset:  IM    
Department of Laboratory Medicine, University-Hospital IRCCS San Martino - IST, National Institute for Cancer Research , Genoa , Italy.
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