Document Detail

Laboratory differentiation of hypercalcemic patients.
MedLine Citation:
PMID:  7055954     Owner:  NLM     Status:  MEDLINE    
We studied the biochemical discrimination of primary hyperparathyroidism from other causes of hypercalcemia. This potentially serious disorder is readily remedied, and because recent work has suggested that even very mild cases in elderly people derive substantial benefit from surgery, the correct diagnosis is crucial. A discriminant function is derived that maximizes the use of data that are readily available from general hospital laboratory; application of the Hamilton "T score" system simplifies its interpretation. We conclude that the best use of this formula is as a negative discriminant, to identify some non-hyperparathyroid cause of hypercalcemia, and also as a partial positive discriminant, to identify some cases of primary hyperparathyroidism. We review previous such discriminants and consider the reasons why they have been less successful.
K R Johnson; A T Howarth; M Hamilton; G C Mascall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  28     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-04-22     Completed Date:  1982-04-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  333-8     Citation Subset:  IM    
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MeSH Terms
Albumins / metabolism
Alkaline Phosphatase / metabolism
Bicarbonates / metabolism
Chlorides / metabolism
Diagnosis, Differential
Hypercalcemia / etiology*
Hyperparathyroidism / complications,  diagnosis*
Phosphates / metabolism
Statistics as Topic
Reg. No./Substance:
0/Albumins; 0/Bicarbonates; 0/Chlorides; 0/Phosphates; EC Phosphatase

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