Document Detail


Laboratory diagnostic outcome applying detection criteria recommended by the Scientific and Standardization Committee of the ISTH on Lupus Anticoagulant.
MedLine Citation:
PMID:  23615569     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study shows the diagnostic outcome of an APTT-based and two dRVVT-based commercial confirmatory integrated tests with the application of the recommendations by the Scientific and Standardization Committee (SSC) on Lupus anticoagulant (LA)/antiphospholipid syndrome (APS) of the International Society on Thrombosis and Haemostasis (ISTH) issued in 2009 concerning the cut-off values for the screening, mixing and confirmatory tests for the detection of LA and the mandatory need to perform mixing tests of patient plasma with pooled normal plasma. The study population included 565 patients collected from a large central coagulation laboratory, for which the attending physicians requested LA detection. One-hundred-six healthy subjects (HS) and 131 selected patients on oral anticoagulant therapy (OAT) were included as negative controls. The results suggest that the performance of mixing tests is indicated for those methods with relatively poor specificity, but is less needed for those methods with high specificity. Furthermore, the SSC recommendation to use normal mid-value (i.e. the 50th percentile of distribution of results from healthy subjects) as the cut-off to interpret results of confirmatory tests, showed a modest increase in LA detection rate (sensitivity) but at the expense of specificity, particularly in methods with low specificity.
Authors:
V Chantarangkul; E Biguzzi; D Asti; C Palmucci; A Tripodi
Related Documents :
24243629 - Prevalence of posttraumatic growth hormone deficiency is highly dependent on the diagno...
25137409 - Maternal plasma dna testing: experience of women counseled at a prenatal diagnosis center.
24055899 - Colorectal cancer screening in palestine: a national study in a medically underserved p...
24829249 - Detection of herpesviridae in whole blood by multiplex pcr dna microarray after hematop...
6885829 - A collaborative assay of mycoplasma reference antisera.
24435599 - Appropriateness of testing for serious bacterial infection in children hospitalized wit...
20151869 - Evaluation of a urine dipstick test for confirmation or exclusion of proteinuria in dogs.
19156679 - Deterring malingered psychopathology: the effect of warning simulating malingerers.
12946919 - A comprehensive assessment of human strivings: test-retest reliability and validity of ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-25
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  110     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Veena Chantarangkul, Via Pace 9, 20122-Milano, Italy, Tel.: +39 02 55035425, Fax: +39 02 5032 0723, E-mail: veena.chantarangkul@policlinico.mi.it.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Not enough doctors or not enough needs? Refocusing health workforce planning from providers and serv...
Next Document:  Tolerance of the small bowel to therapeutic irradiation: a focus on late toxicity in patients receiv...