Document Detail

Laboratory detection of ciprofloxacin resistant Neisseria gonorrhoeae.
MedLine Citation:
PMID:  1907618     Owner:  NLM     Status:  MEDLINE    
During 1989 and 1990 strains of Neisseria gonorrhoeae with reduced susceptibility to ciprofloxacin were isolated in laboratories across the United Kingdom. Treatment failures were associated with some of these infections. These strains were detected by quantitative susceptibility testing because the zone of inhibition around 5 micrograms ciprofloxacin discs shows little decrease in size even with those that are the most resistant. This study determined that strains with reduced susceptibility to ciprofloxacin (MIC of greater than or equal to 0.05 mg/l) produced no zone of inhibition around a commercially available disc containing 30 micrograms of nalidixic acid. Ciprofloxacin sensitive (MIC of less than 0.05 mg/l) strains, however, grew with a large zone (greater than 21 mm) around this disc. These observations suggest that laboratories could adopt this disc test to detect those strains for which ciprofloxacin is not appropriate treatment.
A Turner; A E Jephcott; K R Gough
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  44     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-09-09     Completed Date:  1991-09-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  169-70     Citation Subset:  AIM; IM    
Gonococcus Reference Unit, Public Health Laboratory, Bristol.
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MeSH Terms
Ciprofloxacin / pharmacology*
Drug Resistance, Microbial
Microbial Sensitivity Tests
Neisseria gonorrhoeae / drug effects*,  isolation & purification
Reg. No./Substance:

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