Document Detail


Laboratory and clinical evaluation of the radiation-potentiating activity of ethyl-N-bis (2,2-dimethylethylamidinophosphoro) carbamate (AB-132).
MedLine Citation:
PMID:  1057639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ethyl-N-bis (2,2-dimethylethylamidinophosphoro) carbamate (AB-132) has been shown to potentiate the effect of whole-body radiation on inhibition of splenomegaly induced by Friend leukemia virus in ICR/H Swiss mice. The combined effect of AB-132 and radiation does not appear to be related to Friend virus inhibition but seems to act on the proliferating tumor in the spleen. Nine children with advanced cancer were treated with combined administration of local radiation and systemic AB-132. Although regression of tumor was seem, no dramatic effect on survival was apparent. One case of metastatic Ewing's sarcoma showed systemic tumor response to AB-132 in addition to localized response to radiation. Bone marrow depression appeared to be the main side effect of combination therapy.
Authors:
W Regelson; J Hananian; M Bozzini; C M Ambrus; T J Bardos; J L Ambrus
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of medicine     Volume:  6     ISSN:  0025-7850     ISO Abbreviation:  J Med     Publication Date:  1975  
Date Detail:
Created Date:  1975-12-04     Completed Date:  1975-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505566     Medline TA:  J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-35     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Azirines / therapeutic use*
Child
Female
Friend murine leukemia virus
Humans
Male
Mice
Mice, Inbred ICR
Neoplasm Metastasis
Neoplasms / drug therapy,  radiotherapy
Organ Size
Radiation Effects
Radiation-Sensitizing Agents / therapeutic use*
Spleen / radiation effects
Splenomegaly / etiology,  prevention & control
X-Rays
Chemical
Reg. No./Substance:
0/Azirines; 0/Radiation-Sensitizing Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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