Document Detail


Laboratory approach in Thai patients with venous thrombosis.
MedLine Citation:
PMID:  16858949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This retrospective study aimed to analyze laboratory findings in Thai patients with venous thrombosis in Phramongkutklao Hospital from August 1997 to October 2004. Blood samples obtained from 166 patients with ages ranging from 10 months to 87 years were tested for protein S (PS), protein C (PC), antithrombin (AT), factor V Leiden (FVL) and prothrombin G20210A. It was found that low levels of PS, PC, and AT were observed in 23 patients (13.9%), 21 patients (12.7%) and 11 patients (6.6%), respectively. The incidence of combined low levels of anticoagulant factors occurred in 23 patients (13.9%). Three patients (1.8%) were positive for FVL. All patients were negative for prothrombin G20210A. Additionally, 85 patients (51.2%) were negative for all tests. In conclusion, it is recommended that the screening tests for anticoagulant factors PS, PC and AT be used to investigate the causes of thrombosis in Asian populations due to their cost-effectiveness. However, the detection of gene mutations inducing thrombosis should be considered.
Authors:
Pasra Arnutti; Oytip Nathalang; Wichai Prayoonwiwat; Rachata Lumkul; Chatuporn Pulket
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  88 Suppl 3     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2006-07-24     Completed Date:  2006-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  S116-20     Citation Subset:  IM    
Affiliation:
Department of Pathology, Phramongkutklao College of Medicine, Bangkok, Thailand. parnutti@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antithrombins / metabolism*
Blood Proteins / metabolism*
Child
Child, Preschool
Factor V / genetics*
Female
Humans
Infant
Male
Middle Aged
Prothrombin / genetics*
Retrospective Studies
Thailand
Venous Thrombosis / blood*,  genetics*
Chemical
Reg. No./Substance:
0/Antithrombins; 0/Blood Proteins; 0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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