| Laboratory markers as predictors of mortality in patients with Clostridium difficile infection. | |
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MedLine Citation:
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PMID: 19794314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have identified laboratory markers for severe Clostridium difficile infection (CDI). The most consistent of these markers is the presence of marked leukocytosis. We examined the validity of these markers as predictors of mortality in patients with CDI. We excluded patients with preexisting hematologic conditions that would be expected to impair their ability to demonstrate leukocytosis. On univariate analysis, marked leukocytosis (P = 0.02), thrombocytopenia (P = 0.008), and increased blood urea nitrogen (P < 0.001) and creatinine (P = 0.001) levels were found to be significantly associated with mortality in patients with CDI. However, on logistic regression analysis, only renal impairment was found to be an independent predictor (odds ratio, 5.07). Importantly, in our study, leukocytosis was not an independent predictor after adjustment for other variables, which may be due to our selection criteria when adjusting for confounding variables. We are therefore of the opinion that in immunocompromised hosts who are leukopenic at the time of CDI diagnosis, other laboratory markers should be identified to serve as indicators for severe disease. |
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Authors:
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Chaitanya Pant; Phillip Madonia; Anil Minocha; Kenneth Manas; Paul Jordan; Pat Bass |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of investigative medicine : the official publication of the American Federation for Clinical Research Volume: 58 ISSN: 1708-8267 ISO Abbreviation: J. Investig. Med. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-06 Completed Date: 2010-03-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9501229 Medline TA: J Investig Med Country: Canada |
Other Details:
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Languages: eng Pagination: 43-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Louisiana State University Health Science Center, Shreveport, 71103-4228, USA. cpant@lsuhsc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers Enterocolitis, Pseudomembranous / blood, mortality*, physiopathology Female Humans Kidney / physiopathology Leukocytosis / etiology Male Middle Aged Retrospective Studies Serum Albumin / analysis Thrombocytopenia / etiology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Serum Albumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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