Document Detail


Labor (term and preterm) is associated with changes in the placental mRNA expression of corticotrophin-releasing factor.
MedLine Citation:
PMID:  17636237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Because maternal plasma corticotrophin-releasing factor (CRF) levels increase during the last weeks of pregnancy and at parturition, the present study evaluated whether placental mRNA expression of CRF and CRF-binding protein (CRF-BP) are modified in preterm delivery. A group of 30 women with singleton pregnancies were enrolled in the study. A placental tissue specimen was collected from pregnant women (1) at term after cesarean delivery (39.3 +/- 0.1 gestational weeks; n = 10), (2) at term after spontaneous vaginal delivery (40.1 +/- 0.2 gestational weeks; n = 10), or (3) at preterm delivery (32.4 +/- 0.4 gestational weeks; n = 10). Changes of placental mRNA expression were evaluated by real-time quantitative reverse transcriptase polymerase chain reaction analysis. Placental CRF mRNA expression at term (P < .001) and preterm delivery (P < .001) was significantly higher than in cesarean delivery and highest in preterm placentas. With respect to CRF-BP, no significant difference in placental mRNA expression was observed among samples collected after term or preterm delivery and cesarean delivery. The present study showed for the first time that both term and preterm labor are associated with increased expression of placental CRF but not CRF-BP mRNA.
Authors:
Michela Torricelli; Alessia Giovannelli; Eleonora Leucci; Giulia De Falco; Fernando M Reis; Alberto Imperatore; Pasquale Florio; Felice Petraglia
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  14     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-10-18     Revised Date:  2008-01-21    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-5     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Siena, Siena, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Carrier Proteins / genetics,  metabolism*
Cesarean Section
Corticotropin-Releasing Hormone / genetics,  metabolism*
Female
Gene Expression / physiology
Humans
Labor, Obstetric / genetics,  metabolism*
Obstetric Labor, Premature / genetics,  metabolism*
Placenta / metabolism*
Pregnancy
RNA, Messenger / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/RNA, Messenger; 9015-71-8/Corticotropin-Releasing Hormone

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