Document Detail

Labial salivary gland involvement in neonatal hemochromatosis: a report of 2 cases and review of literature.
MedLine Citation:
PMID:  18585608     Owner:  NLM     Status:  MEDLINE    
Neonatal hemochromatosis (NH) is a severe disease of fetal or perinatal onset, in which iron deposition occurs within hepatic and extrahepatic sites without involving the reticuloendothelial system. Labial minor salivary gland biopsy has been suggested as a diagnostic adjunct in patients suspected of having NH, as hemosiderin accumulates in acinar epithelial cells. Prior to this salivary gland pathology, a diagnosis of NH was often delayed, rendered only after the usual causes of neonatal liver failure had been excluded. Recent studies have shown that early diagnosis and treatment can improve survival. Few cases of salivary gland hemosiderosis in NH have been reported in the literature. A positive finding of salivary gland siderosis on biopsy will expedite care. We report 2 cases of NH, of which a labial salivary gland biopsy supported the diagnosis. The clinical and histological features are presented. The NH literature pertaining to labial salivary gland pathology is reviewed.
King Chong Chan; Morris Edelman; John E Fantasia
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  106     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e27-30     Citation Subset:  D; IM    
Oral and Maxillofacial Pathology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA.
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MeSH Terms
Abnormalities, Multiple
Fatal Outcome
Hemochromatosis / pathology*
Infant, Newborn
Lip / pathology*
Salivary Gland Diseases / pathology*
Salivary Glands, Minor / pathology*

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