Document Detail

Labetalol vs. methyldopa in the treatment of pregnancy-induced hypertension.
MedLine Citation:
PMID:  7649315     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the efficacy and safety of labetalol compared with methyldopa in the management of mild and moderate cases of pregnancy-induced hypertension (PIH). METHODS: One hundred four primigravidas with PIH were randomly allocated to receive either labetalol (group A) or methyldopa (group B). The dose of the drugs was doubled every 48 h to maintain a mean arterial blood pressure < or = 103.6 mmHg. Clinico-biochemical effects and frequency of side effects were studied. The statistical level of significance was taken at P < 0.05. RESULTS: Ten patients in group B (18.5%) developed significant proteinuria (> 30 mg/dl) whereas none developed proteinuria in group A. Labetalol was quicker and more efficient at controlling blood pressure, having a beneficial effect on renal functions and causing fewer side effects compared with methyldopa. The rate of induction of labor and rate of cesarean section for uncontrolled PIH was less in group A (48% and 1%, respectively) compared with group B (63.0% and 5.6%, respectively). Moreover a higher Bishop score at induction of labor was noticed in group A. CONCLUSIONS: Labetalol is better tolerated than methyldopa, gives more efficient control of blood pressure and may have a ripening effect on the uterine cervix.
A M el-Qarmalawi; A H Morsy; A al-Fadly; A Obeid; M Hashem
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  49     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-09-28     Completed Date:  1995-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  125-30     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Al-Jahra Hospital, Jahra, Kuwait.
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MeSH Terms
Blood Pressure / drug effects
Cesarean Section
Dose-Response Relationship, Drug
Drug Administration Schedule
Hypertension / diagnosis,  drug therapy*
Infant, Newborn
Labetalol / adverse effects,  therapeutic use*
Labor, Induced
Methyldopa / adverse effects,  therapeutic use*
Pre-Eclampsia / diagnosis,  drug therapy*
Pregnancy Complications, Cardiovascular / diagnosis,  drug therapy*
Reg. No./Substance:
36894-69-6/Labetalol; 555-30-6/Methyldopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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