Document Detail

Labetalol and other agents that block both alpha- and beta-adrenergic receptors.
MedLine Citation:
PMID:  8124849     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Labetalol, a compound that blocks both alpha- and beta-adrenergic receptors, is the only drug of its class currently available in the United States. OBJECTIVE: To review the pharmacology of labetalol and related compounds. SUMMARY: Unlike "pure" beta blockers, labetalol maintains cardiac output, reduces total peripheral resistance, and does not decrease peripheral blood flow. It has been used to treat hypertension of all degrees of severity and may be especially useful in black patients, elderly patients, patients with renal disease, and in pregnancy. It can be used in conditions that produce catecholamine crises, such as pheochromocytoma, clonidine withdrawal, and cocaine overdose. Its hemodynamic profile is attractive for use in myocardial ischemia. The parenteral form is useful in situations where blood pressure must be lowered quickly. The major side effect is orthostatic hypotension, and hepatotoxicity has been reported. CONCLUSIONS: Labetalol has several advantages over pure beta-blocking drugs and offers an alternative in managing hypertension that is difficult to control.
C J Pearce; J D Wallin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cleveland Clinic journal of medicine     Volume:  61     ISSN:  0891-1150     ISO Abbreviation:  Cleve Clin J Med     Publication Date:    1994 Jan-Feb
Date Detail:
Created Date:  1994-04-12     Completed Date:  1994-04-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8703441     Medline TA:  Cleve Clin J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-69; quiz 80-2     Citation Subset:  IM    
Department of Medicine, Louisiana State University School of Medicine, New Orleans 70112.
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MeSH Terms
Labetalol* / adverse effects,  pharmacology,  therapeutic use
Reg. No./Substance:

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