| Labetalol in hypertensive patients with angina pectoris: beneficial effect of combined alpha- and beta-adrenoreceptor blockade. | |
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MedLine Citation:
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PMID: 32006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Eight hypertensive patients with angina pectoris had placebo added to their existing medications for 8 weeks, then incremental doses of active labetalol with simultaneous stepwise reduction in other medicines until blood pressure was satisfactorily controlled; after that only labetalol and thiazide (8 weeks) and finally labetalol-placebo together with previous beta-adrenoreceptor antagonists and thiazide for 4 weeks were administered. 2. During the labetalol plus thiazide period resting blood pressures and measurements obtained during isotonic exercise, isometric exercise and the cold pressor test were significantly lower than during the initial placebo addition period. Angina scores were significantly reduced during this period. 3. During the final treatment with placebo, beta-adrenoreceptor antagonist and thiazide, blood pressures remained reduced, but angina was significantly worse. 4. Labetalol which antagonizes both alpha- and beta-adrenoreceptors produced better relief of angina pectoris than beta-adrenoreceptor antagonists during improvement in blood pressure in hypertensive patients. |
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Authors:
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W F Lubbe; D A White |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Clinical science and molecular medicine. Supplement Volume: 4 ISSN: 0144-4107 ISO Abbreviation: Clin Sci Mol Med Suppl Publication Date: 1978 Dec |
Date Detail:
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Created Date: 1979-03-24 Completed Date: 1979-03-24 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 7907311 Medline TA: Clin Sci Mol Med Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 283s-286s Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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therapeutic use Adrenergic beta-Antagonists / therapeutic use Adult Aged Angina Pectoris / complications, drug therapy* Clinical Trials as Topic Ethanolamines / therapeutic use* Female Humans Hypertension / complications, drug therapy* Labetalol / therapeutic use* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Ethanolamines; 36894-69-6/Labetalol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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