Document Detail

Labetalol blunts morning pressor surge in systolic hypertension.
MedLine Citation:
PMID:  3278976     Owner:  NLM     Status:  MEDLINE    
Twenty-four-hour ambulatory blood pressure, including the acceleration phase, and left ventricular mass were evaluated in 16 patients with isolated systolic hypertension (standing blood pressure greater than or equal to 160 mm Hg systolic and less than or equal to 95 mm Hg diastolic). After a 4-week, single-blind, placebo period, each patient underwent 24-hour ambulatory blood pressure monitoring and echocardiography. Labetalol therapy was then initiated at 100 mg twice a day in a single-blind manner and increased weekly by 100 mg twice a day until blood pressure control was obtained or a maximum dosage of 400 mg twice a day was reached. Blood pressure control was achieved at a mean daily dose of 363 +/- 46 mg of labetalol. Measurements were repeated at the end of an 8-week maintenance phase. Labetalol therapy significantly reduced the mean 24-hour systolic ambulatory blood pressure from 154 +/- 8 (mean +/- SEM) mm Hg at baseline to 142 +/- 6 mm Hg (p greater than 0.01) and controlled the early morning surge in systolic ambulatory blood pressure. Minor reductions in diastolic blood pressure and heart rate were statistically but not clinically significant. Left ventricular mass was not changed. Labetalol monotherapy provides effective 24-hour control of systolic blood pressure, including the acceleration phase, in patients with isolated systolic hypertension.
V DeQuattro; D D Lee; J Allen; M Sirgo; J Plachetka
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  11     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-04-11     Completed Date:  1988-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I198-201     Citation Subset:  IM    
Hypertension Service, Los Angeles County-University of Southern California Medical Center 90033.
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MeSH Terms
Blood Pressure / drug effects*
Circadian Rhythm
Clinical Trials as Topic
Heart Rate
Hypertension / drug therapy*
Labetalol / therapeutic use*
Middle Aged
Pressoreceptors / physiology
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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