Document Detail

Labeling transplanted mice islet with polyvinylpyrrolidone coated superparamagnetic iron oxide nanoparticles for in vivo detection by magnetic resonance imaging.
MedLine Citation:
PMID:  19687538     Owner:  NLM     Status:  MEDLINE    
Superparamagnetic iron oxide nanoparticles (SPIO) are emerging as a novel probe for noninvasive cell tracking with magnetic resonance imaging (MRI) and have potential wide usage in medical research. In this study, we have developed a method using high-temperature hydrolysis of chelate metal alkoxide complexes to synthesize polyvinylpyrrolidone coated iron oxide nanoparticles (PVP-SPIO), as a biocompatible magnetic agent that can efficiently label mice islet beta-cells. The size, crystal structure and magnetic properties of the as-synthesized nanoparticles have been characterized. The newly synthesized PVP-SPIO with high stability, crystallinity and saturation magnetization can be efficiently internalized into beta-cells, without affecting viability and function. The imaging of 100 PVP-SPIO-labeled mice islets in the syngeneic renal subcapsular model of transplantation under a clinical 3.0 T MR imager showed high spatial resolution in vivo. These results indicated the great potential application of the PVP-SPIO as an MRI contrast agent for monitoring transplanted islet grafts in the clinical management of diabetes in the near future.
Hai Huang; Qiuping Xie; Muxing Kang; Bo Zhang; Hui Zhang; Jin Chen; Chuanxin Zhai; Deren Yang; Biao Jiang; Yulian Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-18
Journal Detail:
Title:  Nanotechnology     Volume:  20     ISSN:  1361-6528     ISO Abbreviation:  Nanotechnology     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-18     Completed Date:  2009-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101241272     Medline TA:  Nanotechnology     Country:  England    
Other Details:
Languages:  eng     Pagination:  365101     Citation Subset:  IM    
Department of Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China.
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MeSH Terms
Biocompatible Materials / chemistry
Cell Proliferation
Cell Survival / physiology
Contrast Media / chemistry
Ferric Compounds / chemistry*
Flow Cytometry
Insulin-Secreting Cells / chemistry*,  cytology,  transplantation*
Kidney / chemistry
Magnetic Resonance Imaging / methods*
Metal Nanoparticles / chemistry*
Mice, Inbred C57BL
Microscopy, Electron, Transmission
Povidone / chemistry*
Staining and Labeling / methods*
Reg. No./Substance:
0/Biocompatible Materials; 0/Contrast Media; 0/Ferric Compounds; 1309-37-1/ferric oxide; 9003-39-8/Povidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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