Document Detail

Label-free optical biosensing with slot-waveguides.
MedLine Citation:
PMID:  18382525     Owner:  NLM     Status:  MEDLINE    
We demonstrate label-free molecule detection by using an integrated biosensor based on a Si(3)N(4)/SiO(2) slot-waveguide microring resonator. Bovine serum albumin (BSA) and anti-BSA molecular binding events on the sensor surface are monitored through the measurement of resonant wavelength shifts with varying biomolecule concentrations. The biosensor exhibited sensitivities of 1.8 and 3.2 nm/(ng/mm(2)) for the detection of anti-BSA and BSA, respectively. The estimated detection limits are 28 and 16 pg/mm(2) for anti-BSA and BSA, respectively, limited by wavelength resolution.
Carlos A Barrios; María José Bañuls; Victoria González-Pedro; Kristinn B Gylfason; Benito Sánchez; Amadeu Griol; A Maquieira; H Sohlström; M Holgado; R Casquel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Optics letters     Volume:  33     ISSN:  0146-9592     ISO Abbreviation:  Opt Lett     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-02     Completed Date:  2008-07-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  708-10     Citation Subset:  IM    
Instituto de Sistemas Optoelectrónicos y Microtecnología, Universidad Politécnica de madrid, ETSI Telecommunicación, Ciudad Universitaria s/n, Madrid, Spain.
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MeSH Terms
Biosensing Techniques / instrumentation*,  methods
Chemistry Techniques, Analytical / methods
Equipment Design
Optics and Photonics*
Sensitivity and Specificity
Serum Albumin, Bovine / chemistry*
Spectrophotometry / methods
Reg. No./Substance:
0/Serum Albumin, Bovine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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