Document Detail


Label-free detection with surface plasmon resonance imaging.
MedLine Citation:
PMID:  21370074     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Sensors based on surface plasmon resonance have demonstrated, over the last 2 decades, to be an effective method of studying biomolecular interactions without the need for labeling. Recently, it has been adapted to high-throughput use for imaging microarray binding in real time. This provides a promising platform - a label-free protein microarray system - for the study of disease. In this example, antibody microarrays are used to efficiently profile the secretion of proteins from a cell line exposed to varying concentrations of a toxic compound.
Authors:
Christopher Lausted; Zhiyuan Hu; Leroy Hood
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  723     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-33     Citation Subset:  IM    
Affiliation:
Institute for Systems Biology, Seattle, WA, USA, clausted@systemsbiology.org.
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