Document Detail

Label-free cellular manipulation and sorting via biocompatible ferrofluids.
MedLine Citation:
PMID:  19995975     Owner:  NLM     Status:  MEDLINE    
We present a simple microfluidic platform that uses biocompatible ferrofluids for the controlled manipulation and rapid separation of both microparticles and live cells. This low-cost platform exploits differences in particle size, shape, and elasticity to achieve rapid and efficient separation. Using microspheres, we demonstrate size-based separation with 99% separation efficiency and sub-10-microm resolution in <45 s. We also show continuous manipulation and shape-based separation of live red blood cells from sickle cells and bacteria. These initial demonstrations reveal the potential of ferromicrofluidics in significantly reducing incubation times and increasing diagnostic sensitivity in cellular assays through rapid separation and delivery of target cells to sensor arrays.
Ayse R Kose; Birgit Fischer; Leidong Mao; Hur Koser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-12-07
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  106     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-18     Completed Date:  2010-02-18     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21478-83     Citation Subset:  IM    
Department of Electrical Engineering, School of Engineering and Applied Sciences, Yale University, New Haven, CT 06520-8284, USA.
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MeSH Terms
Biocompatible Materials*
Cell Separation
Microfluidics / instrumentation
Particle Size
Reg. No./Substance:
0/Biocompatible Materials

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