Document Detail

Labdane diterpenes from the aerial parts of Curcuma comosa enhance fetal hemoglobin production in an erythroid cell line.
MedLine Citation:
PMID:  20196571     Owner:  NLM     Status:  MEDLINE    
Three new labdane diterpenes, curcucomosins A-C (1-3), four known labdane diterpenes, 4-7, and a known diarylheptanoid, 8, were isolated from the aerial parts of Curcuma comosa. The structures of the new diterpenes were elucidated by spectroscopic data analysis. The fetal hemoglobin (Hb F) induction potency of the isolated compounds was examined using a K562 reporter cell line harboring the enhanced green fluorescence protein (EGFP) gene under the control of a (G)gamma-globin promoter. Compound 6, isocoronarin D, exhibited the highest Hb F induction effect of 1.6-fold at 20 microM.
Ratchanaporn Chokchaisiri; Nattawara Chaneiam; Saovaros Svasti; Suthat Fucharoen; Jim Vadolas; Apichart Suksamrarn
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of natural products     Volume:  73     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  724-8     Citation Subset:  IM    
Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
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MeSH Terms
Curcuma / chemistry*
Diterpenes / chemistry,  isolation & purification*,  pharmacology*
Erythroid Cells / drug effects
Fetal Hemoglobin / drug effects*,  metabolism
Green Fluorescent Proteins / diagnostic use,  genetics
K562 Cells
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Reg. No./Substance:
0/Diterpenes; 0/curcucomosin A; 0/curcucomosin B; 0/curcucomosin C; 0/enhanced green fluorescent protein; 147336-22-9/Green Fluorescent Proteins; 9034-63-3/Fetal Hemoglobin

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