| Lab on a chip phased-array MR multi-platform analysis system. | |
| | |
MedLine Citation:
|
PMID: 22200053 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
We present a lab on a chip (LOC) compatible modular platform for magnetic resonance (MR)-based investigation of sub-millimetre samples. The platform combines the advantages offered respectively by microcoils (high resolution at the microscale) and macroscopic surface coils (large field of view) as MR-detectors and consists of a phased array of microcoils (PAMs) providing a flat MR-sensitive area of 18.3 mm(2) with a B(0)-field uniformity better than 0.25 ppm in the sensor centre area. We demonstrate both high-resolution magnetic resonance imaging (MRI) and NMR spectroscopy using this platform. To demonstrate the application for biological samples, we report MR imaging of fish oocytes with an in-plane resolution of 30 × 30 μm(2) and a contrast to noise ratio of 10 for a scan time of only 13 min 39 s. We have also demonstrated high-resolution spectroscopy of a water phantom achieving 11 ppb (4.5 Hz at 400 MHz) linewidth and an SNR of 28 for only 12 s scan time. State of the art automatic wire bonding technology in conjunction with MEMS techniques has been employed to manufacture the platform with potential applications in MR-investigation of planar samples. |
| | |
Authors:
|
Oliver G Gruschke; Nicoleta Baxan; Lars Clad; Kai Kratt; Dominik von Elverfeldt; Andreas Peter; Jürgen Hennig; Vlad Badilita; Ulrike Wallrabe; Jan G Korvink |
Related Documents
:
|
21835253 - A comprehensive testing protocol for mri neuroanatomical segmentation techniques: evalu... 1857923 - Hemichorea-hemiballism and anosognosia following a contralateral infarction of the caud... 21835253 - A comprehensive testing protocol for mri neuroanatomical segmentation techniques: evalu... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-23 |
Journal Detail:
|
Title: Lab on a chip Volume: - ISSN: 1473-0189 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101128948 Medline TA: Lab Chip Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University of Freiburg, Department of Microsystems Engineering (IMTEK), Lab of Simulation, Georges-Köhler-Allee 103, 79110, Freiburg, Germany. gruschke@imtek.de vlad.badilita@imtek.de korvink@imtek.de. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Use of fungal derived polysaccharide-conjugated particles to probe Dectin-1 responses in innate immu...
Next Document: ZnO-ZnGa(2)O(4) core-shell nanowire array for stable photoelectrochemical water splitting.