Document Detail

Lab on a chip packing of submicron particles for high performance EOF pumping.
MedLine Citation:
PMID:  20926092     Owner:  NLM     Status:  MEDLINE    
The packing of submicrometer sized silica beads inside a microchannel was enabled by a novel method which avoids the complication and limitations of generating a frit using conventional approaches and the restriction of flow using a submicrometer sized weir. A micrometer sized weir and two short columns of 5 μm and 800 nm silica beads packed in succession behind the weir together functioned as a high pressure frit to allow the construction of a primary packed bed of 390 nm silica beads. This packed bed microchannel was tested as an EOF pump, wherein it exhibited superior performance with regards to pressure tolerance, i.e., sustaining good flow rate under extremely high back pressure, and maximal pressure generation. Under a modest applied electric field strength of 150 V/cm, the flow rate against a back pressure of 1200 psi (∼8.3 MPa) was 40 nL/min, and the maximal pressure reached 1470 psi (∼10 MPa). This work has demonstrated that it is possible to create a high performance packed bed microchannel EOF pump using nanometer sized silica beads, as long as proper care is taken during the packing process to minimize the undesirable mixing of two different sized particles at the boundaries between particle segments and to maximize the packing density throughout the entire packed bed.
Qin Lu; Greg E Collins
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-09-15
Journal Detail:
Title:  Journal of chromatography. A     Volume:  1217     ISSN:  1873-3778     ISO Abbreviation:  J Chromatogr A     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9318488     Medline TA:  J Chromatogr A     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  7153-7     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
Naval Research Laboratory, 4555 Overlook Ave., SW Chemistry Division, Code 6112, Washington, DC 20375-5342, USA.
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MeSH Terms
Drug Stability
Electroosmosis / instrumentation*,  methods*
Equipment Design
Lab-On-A-Chip Devices*
Microscopy, Electron, Scanning
Models, Theoretical
Nanoparticles / ultrastructure*
Particle Size
Silicon Dioxide
Reg. No./Substance:
7631-86-9/Silicon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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