Document Detail


LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.
MedLine Citation:
PMID:  11294389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several LY294002-GM heterodimers were synthesized with the intent of modulating their activity in the presence of hsp90 and thereby creating selective inhibitors of PI3K and PI3K-related family.
Authors:
G Chiosis; N Rosen; L Sepp-Lorenzino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  11     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-10     Completed Date:  2001-09-06     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  909-13     Citation Subset:  IM    
Affiliation:
Department of Molecular Oncogenesis, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. chiosisg@mskmail.mskcc.org
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MeSH Terms
Descriptor/Qualifier:
Benzoquinones
Cell Cycle Proteins
Chromones / chemistry,  pharmacology*
DNA-Activated Protein Kinase
DNA-Binding Proteins*
Dimerization
HSP90 Heat-Shock Proteins / chemistry,  metabolism
Inhibitory Concentration 50
Lactams, Macrocyclic
Morpholines / chemistry,  pharmacology*
Phosphatidylinositol 3-Kinases / antagonists & inhibitors*
Protein-Serine-Threonine Kinases / antagonists & inhibitors*,  chemistry,  metabolism
Quinones / chemistry,  pharmacology*
Tumor Suppressor Proteins
Chemical
Reg. No./Substance:
0/Benzoquinones; 0/Cell Cycle Proteins; 0/Chromones; 0/DNA-Binding Proteins; 0/HSP90 Heat-Shock Proteins; 0/Lactams, Macrocyclic; 0/Morpholines; 0/Quinones; 0/Tumor Suppressor Proteins; 154447-36-6/2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; 30562-34-6/geldanamycin; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC 2.7.11.1/DNA-Activated Protein Kinase; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/ataxia telangiectasia mutated protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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