Document Detail

LV dyssynchrony as assessed by phase analysis of gated SPECT myocardial perfusion imaging in patients with Wolff-Parkinson-White syndrome.
MedLine Citation:
PMID:  22532253     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this study was to evaluate left ventricular (LV) mechanical dyssynchrony in patients with Wolff-Parkinson-White (WPW) syndrome pre- and post-radiofrequency catheter ablation (RFA) using phase analysis of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI).
METHODS: Forty-five WPW patients were enrolled and had gated SPECT MPI pre- and 2-3 days post-RFA. Electrophysiological study (EPS) was used to locate accessory pathways (APs) and categorize the patients according to the AP locations (septal, left and right free wall). Electrocardiography (ECG) was performed pre- and post-RFA to confirm successful elimination of the APs. Phase analysis of gated SPECT MPI was used to assess LV dyssynchrony pre- and post-RFA.
RESULTS: Among the 45 patients, 3 had gating errors, and thus 42 had SPECT phase analysis. Twenty-two patients (52.4%) had baseline LV dyssynchrony. Baseline LV dyssynchrony was more prominent in the patients with septal APs than in the patients with left or right APs (p < 0.05). RFA improved LV synchrony in the entire cohort and in the patients with septal APs (p < 0.01).
CONCLUSION: Phase analysis of gated SPECT MPI demonstrated that LV mechanical dyssynchrony can be present in patients with WPW syndrome. Septal APs result in the greatest degree of LV mechanical dyssynchrony and afford the most benefit after RFA. This study supports further investigation in the relationship between electrical and mechanical activation using EPS and phase analysis of gated SPECT MPI.
Chun Chen; Dianfu Li; Changqing Miao; Jianlin Feng; Yanli Zhou; Kejiang Cao; Michael S Lloyd; Ji Chen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-04-25
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  39     ISSN:  1619-7089     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-07     Completed Date:  2012-12-19     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1191-8     Citation Subset:  IM    
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
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MeSH Terms
Accessory Atrioventricular Bundle / complications,  pathology,  radionuclide imaging*
Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography / methods
Catheter Ablation / methods
Echocardiography / methods
Electrocardiography / methods
Electrophysiologic Techniques, Cardiac / methods
Middle Aged
Myocardial Perfusion Imaging / methods
Radiopharmaceuticals / diagnostic use
Technetium Tc 99m Sestamibi / diagnostic use*
Ventricular Dysfunction, Left / etiology,  pathology,  radionuclide imaging*
Wolff-Parkinson-White Syndrome / complications,  pathology,  radionuclide imaging*
Grant Support
Reg. No./Substance:
0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi

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