Document Detail


LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation.
MedLine Citation:
PMID:  20728949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
LRRK2, the causal molecule of familial Parkinson's disease, is expressed strongly by one of the B cell subsets, B-2 cells, but not by the other subset, B-1 cells, in the mouse peritoneal cavity, spleen, and peripheral blood. Bone marrow pre-B cells or T cells exhibited little LRRK2 expression. LRRK2 expression was dramatically downregulated upon activation of B-2 cells with various types of stimulation. These results suggest that LRRK2, whose true function has not yet been clarified, may play some important role(s) in the development and function of B cells, particularly the maintenance of B-2 cells in a resting status.
Authors:
Makoto Kubo; Yoshiko Kamiya; Ryuichi Nagashima; Tatsunori Maekawa; Koji Eshima; Sadahiro Azuma; Etsuro Ohta; Fumiya Obata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-21
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  229     ISSN:  1872-8421     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2010-12-17     Revised Date:  2012-06-22    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  123-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Division of Clinical Immunology, Graduate School of Medical Sciences, Kitasato University, Minami-ku, Sagamihara, Kanagawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
B-Lymphocyte Subsets / drug effects,  metabolism*
Down-Regulation / drug effects,  genetics,  immunology*
Female
Flow Cytometry / methods
Ionomycin / pharmacology
Ionophores / pharmacology
Lipopolysaccharides / pharmacology
Mice
Mice, Inbred C57BL
Mice, Knockout
Protein-Serine-Threonine Kinases / deficiency,  genetics,  metabolism*
RNA, Messenger / metabolism
Tetradecanoylphorbol Acetate / analogs & derivatives,  pharmacology
Chemical
Reg. No./Substance:
0/Ionophores; 0/Lipopolysaccharides; 0/RNA, Messenger; 16561-29-8/Tetradecanoylphorbol Acetate; 56092-81-0/Ionomycin; 57716-89-9/4-O-methyl-12-O-tetradecanoylphorbol 13-acetate; EC 2.7.11.1/Lrrk2 protein, mouse; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.25/NF-kappa B kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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