| LRRK2 I2020T mutation is associated with tau pathology. | |
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MedLine Citation:
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PMID: 22525366 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal-dominant familial Parkinson's disease (FPD). The variable pathological features of LRRK2-linked FPD include Lewy bodies, degeneration of anterior horn cells associated with axonal spheroids, neurofibrillary tangles (NFTs) and TAR DNA-binding protein of 43 kDa (TDP-43) positive inclusion bodies. Furthermore, abnormal hyperphosphorylation of microtubule associated protein tau, in part generated by catalysis of protein kinases, has been reported to be involved in progressive neurodegeneration in a number of diseases, including FPD. Thus, we examined six patients carrying the LRRK2 I2020T mutation, a pathogenic mutation associated with PARK8, and found abnormal tau phosphorylation depositions in the brainstem. Additionally, we found LRRK2 I2020T enhanced tau phosphorylation in cultured cells co-expressing LRRK2-I2020T and 3 or 4-repeated tau. This is the first report describing the relationship between hyperphosphorylation of tau and LRRK2 I2020T. |
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Authors:
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Sachiko Ujiie; Taku Hatano; Shin-Ichiro Kubo; Satoshi Imai; Shigeto Sato; Toshiki Uchihara; Saburo Yagishita; Kazuko Hasegawa; Hisayuki Kowa; Fumihiko Sakai; Nobutaka Hattori |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-21 |
Journal Detail:
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Title: Parkinsonism & related disorders Volume: - ISSN: 1873-5126 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513583 Medline TA: Parkinsonism Relat Disord Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Neurology, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Department of Neurology, Kitasato University, School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0329, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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