Document Detail


LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression.
MedLine Citation:
PMID:  16941076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
LRRC4 (leucine rich repeat containing 4), a novel member of LRP (Leucine-rich repeat protein) superfamily, contains a conserved leucine-rich repeat (LRR) cassette and an immunoglobulin-like (IgC2) domain in its extracellular region. In the present study, we demonstrated that the N and C terminal LRR (LRRNT and LRRCT) are requisite for membrane and cytoplasm location of LRRC4 in Cos7 cells. We also suggested that RPTP-zeta (receptor-type protein tyrosine phosphatase) receptor is relevant to the invasion ability of gliomas cells, and its expression is inhibited by the reexpression of LRRC4. Our observations indicated that LRRC4 may be a negative regulator of the RPTP-zeta receptor, and contribute to suppressing the invasion ability of gliomas cells.
Authors:
Minghua Wu; Kai Gan; Chen Huang; Yunlian Tang; Qiong Chen; Ke Tang; Xiaoling Li; Shourong Shen; Guiyuan Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-29
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  80     ISSN:  0167-594X     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-24     Completed Date:  2007-01-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  133-42     Citation Subset:  IM    
Affiliation:
Cancer Research Institute, Central South University, Changsha, 410078 Hunan, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Cell Communication / physiology
Cells, Cultured
Central Nervous System Neoplasms / genetics*,  pathology*
Diffusion Chambers, Culture
Gap Junctions / physiology
Gene Deletion
Glioblastoma / genetics*,  pathology*
Glyceraldehyde-3-Phosphate Dehydrogenases / physiology
Humans
Microscopy, Fluorescence
Molecular Sequence Data
Neoplasm Invasiveness / genetics,  pathology
Nerve Tissue Proteins / physiology*
Plasmids / genetics
Protein Tyrosine Phosphatases / antagonists & inhibitors*,  biosynthesis*
Receptor-Like Protein Tyrosine Phosphatases, Class 5
Recombinant Fusion Proteins / genetics
Reverse Transcriptase Polymerase Chain Reaction
Scrapie / pathology
Transfection
Chemical
Reg. No./Substance:
0/LRRC4 protein, human; 0/Nerve Tissue Proteins; 0/Recombinant Fusion Proteins; EC 1.2.1.-/Glyceraldehyde-3-Phosphate Dehydrogenases; EC 3.1.3.48/PTPRZ1 protein, human; EC 3.1.3.48/Protein Tyrosine Phosphatases; EC 3.1.3.48/Receptor-Like Protein Tyrosine Phosphatases, Class 5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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