| LPS-induced TNFα factor (LITAF) in the snail Cipangopaludina chinensis: Gene cloning and its apoptotic effect on NCI-H446 cells. | |
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MedLine Citation:
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PMID: 22138218 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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LPS-induced TNFα factor (LITAF) is a transcription factor mediating TNF-α expression under LPS stimulation, and playing important roles in immune responses. In the present study, partial cDNA sequence of a LITAF (designated CcLITAF) gene was cloned and identified from snail Cipangopaludina chinensis. It contains an open reading frame of 348 nucleotides encoding a predicted protein of 115 amino acids, with a conserved LITAF domain at C-terminal, and shares a similarity ranging from 34% to 96% with other LITAF from oyster to mammals. CcLITAF mRNA ubiquitously expressed in all analyzed tissues. Interestingly, cLITAF could induce apoptosis in human tumor cell line, NCI-H446 cells, and caspase 3 play key roles in CcLITAF-mediated apoptosis. Present studies provide new insight into the biological function of CcLITAF. |
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Authors:
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Shoubao Yang; Peifen Li; Zhongxiang Mi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-25 |
Journal Detail:
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Title: Fish & shellfish immunology Volume: - ISSN: 1095-9947 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505220 Medline TA: Fish Shellfish Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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College of Life Sciences, Shaoxing University, No. 900, South City Road, Shaoxing, 312000, China; College of Animal Sciences, Zhejiang University, No. 268, Kaixuan Roud, Hangzhou, 310029, China. |
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