| LPS fever in old rats depends on the ambient temperature. | |
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MedLine Citation:
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PMID: 12782220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In earlier work, we found that following lipopolysaccharide (LPS) injection at an ambient temperature (Ta) of 23 degrees C, old rats developed blunted fevers compared with those of young rats. However, the old rats did become febrile if placed in a thermally graded alleyway: they spent more time in the warm end of the gradient and developed a significantly higher body temperature (Tb) than they did following saline injections. In the present experiments, we maintained old and young rats for 3 days at 20 or 31 degrees C (the Ta preferred by the old rats given LPS). After LPS (50 microg/kg ip), the young rats developed equivalent fevers at both Ta's. The old rats developed fevers that were equivalent to those of the young rats at 31 degrees C. At 20 degrees C, their fever was significantly lower. These results suggest that Ta plays a decisive role in the ability of old rats to mount febrile responses. |
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Authors:
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E D Peloso; M Florez-Duquet; J B Buchanan; E Satinoff |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Physiology & behavior Volume: 78 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-06-03 Completed Date: 2004-01-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 651-4 Citation Subset: IM |
Affiliation:
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Psychology Department, University of Delaware, Newark, DE 19716, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Body Temperature / drug effects, physiology Body Weight / physiology Female Fever / chemically induced*, physiopathology* Lipopolysaccharides / toxicity* Male Rats Rats, Long-Evans Temperature |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH 41138/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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