| LOC387761 polymorphism is associated with type 2 diabetes in the Mexican population. | |
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MedLine Citation:
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PMID: 21198374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Worldwide researchers have invested time, effort, and money during the last years to find new genes associated with diabetes susceptibility, such as LOC387761, HHEX, EXT2, and SLC30A8. The aim of the present study was to evaluate whether single-nucleotide polymorphisms (SNPs) of these genes are associated with type 2 diabetes (T2D) and metabolic traits in the Mexican population. We also assessed these SNPs in Mexican indigenous groups to identify a possible inherited susceptibility. Seven SNPs were analyzed in 789 Mexicans (234 control subjects, 455 type 2 diabetic patients, and 100 of indigenous origin), using the KASPar assay (KBioscience Company). Analysis of the data showed an association of the LOC387761 SNP rs7480010 with T2D (p = 0.019). The risk allele A of rs7480010 increased body mass index in diabetic patients (p = 0.01). In addition, there was no association between T2D and the SNPs of HHEX, EXT2, and SLC30A8. Our findings suggest that the SNP rs7480010 (LOC387761) can contribute to a failure in insulin secretion, thus increasing the susceptibility to T2D in Mexicans. |
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Authors:
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Roxana Gutiérrez-Vidal; Adriana Rodríguez-Trejo; Samuel Canizales-Quinteros; Martín Herrera-Cornejo; Maria Angeles Granados-Silvestre; Isela Montúfar-Robles; María Guadalupe Ortiz-López; Marta Menjívar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-01-03 |
Journal Detail:
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Title: Genetic testing and molecular biomarkers Volume: 15 ISSN: 1945-0257 ISO Abbreviation: Genet Test Mol Biomarkers Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: 2011-07-19 Revised Date: 2011-08-27 |
Medline Journal Info:
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Nlm Unique ID: 101494210 Medline TA: Genet Test Mol Biomarkers Country: United States |
Other Details:
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Languages: eng Pagination: 79-83 Citation Subset: IM |
Affiliation:
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Facultad de Química, Universidad Nacional Autónoma de México, México, México. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Body Mass Index Cation Transport Proteins / genetics Diabetes Mellitus, Type 2 / ethnology, genetics* Genetic Predisposition to Disease* Genotype Homeodomain Proteins / genetics Humans Insulin / genetics, secretion Mexico N-Acetylglucosaminyltransferases / genetics Polymorphism, Single Nucleotide* Transcription Factors / genetics |
| Chemical | |
Reg. No./Substance:
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0/Cation Transport Proteins; 0/HHEX protein, human; 0/Homeodomain Proteins; 0/SLC30A8 protein, human; 0/Transcription Factors; 11061-68-0/Insulin; EC 2.4.1.-/N-Acetylglucosaminyltransferases; EC 2.4.1.224/exostosin-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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